| | Subsystem | Classification | Scope | Challenge | Suggested by | Claimed by | Comments |
| 1 | Lysine biosynthesis AAA pathway | Amino Acids and Derivatives/Lysine, threonine, methionine, and cysteine | NEW | High | AO | Benjamin Sloniker** | Consult with Andrei Osterman |
| 2 | 3-hydroxypropionate cycle of CO2-fixation | Carbohydrates/Central carbohydrate metabolism | NEW | Medium | VC | | | |
| 3 | Carboxysome | Carbohydrates/CO2 fixation | NEW | Basic | SG | Malgorzata Gil (*6:45AM) | |
| 4 | Acetyl-CoA pathway of CO2 fixation | Carbohydrates/CO2 fixation | NEW | Basic | SG | Heather Tyler (*11:36AM) | |
| 5 | Reductive TCA cycle of CO2 fixation | Carbohydrates/CO2 fixation | NEW | Medium | SG | Lilian Waiboci (*8:08AM) | Coordinate with TCA SS |
| 6 | Pectin Degradation | Carbohydrates/Polysaccharide Metabolism | NEW | Medium | DR | Shengde Zhou | |
| 7 | Isocitrate Lyase independent glyoxylate cycle | Carbohydrates/Central carbohydrate metabolism | NEW | Medium | VC | Phi Minh Do (*8:48PM) | | |
| 8 | Poly-beta-hydroxybutanoate metabolism | Carbohydrates/Organic acid metabolism | NEW | Medium | SG | Youngyun Kim | |
| 9 | Cellulosome of bacteria | Carbohydrates/Polysaccharide Metabolism | NEW | High | VC | Franz St. John (*2:08PM) | |
| 10 | D-alanyl-lipoteichoic acid biosynthesis | Cell Wall and Capsule/Gram-Positive cell wall components | NEW | Basic | OZ | Elliot Miller (*7:08AM) | Coordinate with Teichoic acid biosynthesis SS |
| 11 | Teichoic acid biosynthesis | Cell Wall and Capsule Gram-Positive cell wall components | NEW | Medium | OZ | Cindy Capestany (*7:08PM) | Coordinate with D-alanyl-lipoteichoic acid biosynthesis SS |
| 12 | Pyridoxine biosynthesis | Cofactors, Vitamins, Prosthetic Groups, Pigments | NEW | High | DR | Eunmin Cho | |
| 13 | Cobalamin (vitamin B12) biosynthesis | Cofactors, Vitamins, Prosthetic Groups, Pigments | NEW | High | DR | | |
| 14 | Molybdenium cofactor biosynthesis | Cofactors, Vitamins, Prosthetic Groups, Pigments/Folate and pterins | NEW | Basic | VC | Diane Holder (*7:53AM) | |
| 15 | F420 cofactor biosynthesis | Cofactors, Vitamins, Prosthetic Groups, Pigments/Folate and pterins | NEW | Basic | VC | Amy Wright (*8:58AM) | |
| 16 | Folate biosynthesis v.2 | Cofactors, Vitamins, Prosthetic Groups, Pigments/Folate and pterins | UPGRADE | High | VC | | Consult with Dr. de Crecy Lagard |
| 17 | Tetrahydrobiopterin biosynthesis, and regeneration | Cofactors, Vitamins, Prosthetic Groups, Pigments/Folate and pterins | UPGRADE | Medium | VC | Dr.Madeline Rasche | Consult with Dr. de Crecy Lagard |
| 18 | Pyrroloquinoline quinone biosynthesis | Cofactors, Vitamins, Prosthetic Groups, Pigments/Protein derived cofactor | NEW | High | OZ | Jonathan Moore (*6:45AM) | |
| 19 | Anaerobic_benzoate_metabolism | Degradation of Xenobiotics | NEW | Medium | OV | Matthew Humbard** | |
| 20 | Benzoate degradation | Metabolism of aromatic compounds | NEW | Basic | OV | Changhao Bi | |
| 21 | Biphenyl degradation | Metabolism of aromatic compounds | NEW | Basic | OV | Guang Nong | |
| 22 | Hydroxyphenylpropionate catabolism | Metabolism of aromatic compounds | NEW | Basic | OV | Dr.Brett Kirkland |
| 23 | Phenylpropanoid biosynthesis in bacteria | Metabolism of aromatic compounds | NEW | Medium | OV | Jian Song | |
| 24 | Proteolysis, ATP-dependent in bacteria | Protein Metabolism/Protein Degradation | NEW | Basic | VC | Johnny Davis (*8:27AM) | |
| 25 | Queuosine and Archaeosine biosynthesis | RNA metabolism/RNA processing and modification | UPGRADE | High | VC | Carol Bonner | Consult with Dr. de Crecy Lagard |
| 26 | Envelope stress response in E.coli | Stress response | NEW | High | VC | Dr.Julie Maupin | Consult with Dr. de Crecy Lagard |
| 27 | Aliphatic sulfonate utilization in bacteria | Sulfur metabolism | NEW | Medium | OV | | |
| 28 | CcrM and cell cycle regulation in bacteria | Cell Division and Cell Cycle | NEW | High | PP | Priscilla Phillips | |
* - PST of the e.mail request was applied as one of the priority factors
** - automatic assignment, renegotiation is possible