| Subsystem | Unique roles | Total roles | Curator | Status |
| Coenzyme_A_Biosynthesis | 12 | 13 | AndreiO | done |
| Lysine_Biosynthesis_DAP_Pathway | 14 | 16 | AndreiO | done |
| NAD_and_NADP_cofactor_biosynthesis_global | 23 | 24 | AndreiO | done |
| Phenylalanine_and_Tyrosine_Branches_from_Chorismate | 10 | 15 | carolb |
| Fatty_Acid_Biosynthesis_FASII | 13 | 13 | ChenY | done |
| Methionine_Degradation | 0 | 0 | ChenY | |
| Inorganic_Sulfur_Assimilation | 15 | 15 | ChristianR | |
| Lactose_and_Galactose_Uptake_and_Utilization | 10 | 12 | OlgaZ | |
| Colanic_acid_biosynthesis | 2 | 2 | JenZ | |
| Anaerobic_respiratory_reductases | 0 | 1 | OlgaV | |
| Na(+)-translocating_NADH-quinone_oxidoreductase_and_rnf-like_group_of_electron_transport_complexes | 0 | 0 | OlgaV | |
| One-carbon_metabolism_by_tetrahydropterines | 1 | 5 | OlgaV | |
| Phosphate_metabolism | 5 | 6 | OlgaV | |
| Polyhydroxybutyrate_metabolism | 3 | 10 | OlgaV | |
| Purine_Utilization | 5 | 6 | OlgaV | |
| Purine_conversions | 26 | 29 | OlgaV | |
| Respiratory_Complex_I | 13 | 13 | OlgaV | |
| Respiratory_dehydrogenases_1 | 2 | 7 | OlgaV | |
| Serine-glyoxylate_cycle | 11 | 29 | OlgaV |
| Succinate_dehydrogenase | 5 | 7 | OlgaV | |
| TCA_Cycle | 21 | 30 | OlgaV | |
| Teichoic_and_lipoteichoic_acids_biosynthesis | 3 | 4 | OlgaV | |
| Terminal_cytochrome_C_oxidases | 0 | 0 | OlgaV | |
| Terminal_cytochrome_oxidases | 0 | 0 | OlgaV | |
| Threonine_degradation | 4 | 6 | OlgaV | |
| Triacylglycerol_metabolism | 5 | 5 | OlgaV | |
| Acetyl-CoA_fermentation_to_Butyrate | 4 | 13 | OlgaZ | |
| Alanine_biosynthesis | 2 | 7 | OlgaZ | done |
| Arginine_Biosynthesis_extended | 8 | 9 | OlgaZ | |
| Arginine_and_Ornithine_Degradation | 16 | 21 | OlgaZ | |
| Choline_and_Betaine_Uptake_and_Betaine_Biosynthesis | 3 | 3 | OlgaZ | |
| D-Galacturonate_Utilization | 5 | 7 | OlgaZ | |
| D-Sorbitol(D-Glucitol)_and_L-Sorbose_Utilization | 2 | 2 | OlgaZ | |
| D-ribose_utilization | 0 | 1 | OlgaZ | done |
| Deoxyribose_and_Deoxynucleoside_Catabolism | 1 | 5 | OlgaZ | |
| Glutamine,_Glutamate,_Aspartate_and_Asparagine_Biosynthesis | 14 | 18 | OlgaZ | |
| Glycerol_and_Glycerol-3-phosphate_Uptake_and_Utilization | 3 | 10 | OlgaZ | |
| Glycerolipid_and_Glycerophospholipid_Metabolism_in_Bacteria | 11 | 18 | OlgaZ | |
| Isoleucine_degradation | 0 | 0 | OlgaZ | |
| Isoprenoid_Biosynthesis | 12 | 17 | OlgaZ | |
| KDO2-Lipid_A_biosynthesis | 13 | 13 | OlgaZ | |
| LOS_core_oligosaccharide_biosynthesis | 7 | 7 | OlgaZ | |
| Maltose_and_Maltodextrin_Utilization | 2 | 4 | OlgaZ | |
| Mannose_Metabolism | 4 | 4 | OlgaZ | |
| Menaquinone_and_Phylloquinone_Biosynthesis | 9 | 10 | OlgaZ | |
| Methylglyoxal_Metabolism | 6 | 6 | OlgaZ | |
| Pyridoxin_(Vitamin_B6)_Biosynthesis | 7 | 10 | OlgaZ | |
| Pyruvate_Alanine_Serine_Interconversions | 8 | 13 | OlgaZ | |
| Serine_Biosynthesis | 4 | 6 | OlgaZ | |
| Sialic_Acid_Metabolism | 7 | 13 | OlgaZ | |
| Sucrose_utilization | 1 | 2 | OlgaZ | |
| Threonine_and_Homoserine_Biosynthesis | 1 | 6 | OlgaZ | |
| Trehalose_Biosynthesis | 3 | 3 | OlgaZ | |
| Trehalose_Uptake_and_Utilization | 4 | 6 | OlgaZ | |
| UDP-N-acetylmuramate_from_Fructose-6-phosphate_Biosynthesis | 3 | 9 | OlgaZ | done |
| Ubiquinone_Biosynthesis | 9 | 10 | OlgaZ | |
| Valine_degradation | 7 | 15 | OlgaZ | |
| dTDP-rhamnose_synthesis | 4 | 4 | OlgaZ | |
| F0-F1-type_ATP_synthase | 0 | 0 | RickS | |
| Peptidoglycan_Biosynthesis | 10 | 15 | RickS | |
| Proline_Synthesis | 3 | 3 | RickS | |
| Biotin_biosynthesis | 6 | 6 | rodionov | |
| Chitin_and_N-acetylglucosamine_utilization | 4 | 6 | rodionov | |
| D-galactarate,_D-glucarate_and_D-glycerate_catabolism | 5 | 6 | rodionov | |
| Fructose_utilization | 2 | 3 | rodionov | |
| L-Arabinose_utilization | 3 | 3 | rodionov | |
| Lactate_utilization | 2 | 3 | rodionov | |
| Methionine_Biosynthesis | 21 | 24 | rodionov | |
| Nitrate_and_nitrite_ammonification | 13 | 13 | rodionov | |
| Riboflavin,_FMN_and_FAD_metabolism | 12 | 12 | rodionov | |
| Ribonucleotide_reduction | 5 | 5 | rodionov | |
| Thiamin_biosynthesis | 14 | 14 | rodionov | |
| Urea_decomposition | 6 | 6 | rodionov | |
| Xylose_utilization | 2 | 2 | rodionov | |
| Branched-Chain_Amino_Acid_Biosynthesis | 8 | 13 | RossO | |
| De_Novo_Purine_Biosynthesis | 15 | 17 | RossO | |
| De_Novo_Pyrimidine_Synthesis | 12 | 12 | RossO | |
| Histidine_Biosynthesis | 12 | 13 | RossO | |
| Histidine_Degradation | 8 | 8 | RossO | |
| Calvin-Benson_cycle | 4 | 14 | SvetaG | |
| Cytochrome_B6-F_complex | 0 | 0 | SvetaG | |
| D-gluconate_and_ketogluconates_metabolism | 3 | 3 | SvetaG | |
| Embden-Meyerhof_and_Gluconeogenesis | 10 | 25 | SvetaG | |
| Entner-Doudoroff_Pathway | 9 | 23 | SvetaG | |
| Fermentations_Lactate | 5 | 9 | SvetaG | |
| Fermentations_Mixed_acid | 1 | 5 | SvetaG | |
| Glycine_cleavage_system | 4 | 5 | SvetaG | |
| Glycogen_metabolism | 5 | 5 | SvetaG | |
| Heme,_hemin_uptake_and_utilization_systems_in_Gram-Positives | 0 | 0 | SvetaG | |
| Pentose_phosphate_pathway | 2 | 11 | SvetaG | |
| Photosystem_I | 0 | 0 | SvetaG | |
| Photosystem_II | 0 | 0 | SvetaG | |
| Polyamine_Metabolism | 6 | 9 | SvetaG | |
| Pyruvate_metabolism_I:_anaplerotic_reactions,_PEP | 12 | 17 | SvetaG | |
| Pyruvate_metabolism_II_acetyl-CoA,_acetogenesis_from_pyruvate | 9 | 13 | SvetaG | |
| Folate_Biosynthesis | 13 | 17 | vcrecy | |
| Chlorophyll_Biosynthesis | 8 | 8 | VeronikaV | |
| Chorismate_Synthesis | 13 | 18 | VeronikaV | |
| Leucine_Degradation_and_HMG-CoA_Metabolism | 8 | 17 | VeronikaV | |
| Photosystem_II-type_photosynthetic_reaction_center | 0 | 0 | VeronikaV | |
| Tryptophan_synthesis | 7 | 9 | VeronikaV | |
